Failure to vaccinate against whooping cough.

EVALUATION OF SERUM OPSONIC CAPACITY AGAINST BORDETELLA PERTUSSIS BY CHEMILUMINESCENCE

Serum opsonic capacity against B. pertussis was studied by using quantitative chemiluminescence (CL), a method known to have several advantages over conventional methods in evaluating opsonization and phagocytosis. Sera from unvaccinated infants was shown not to contain opsonins against B. pertussis and in unvaccinated infants suffering from whooping cough, no opsonins were detected. In ad...

Attack rates of notified whooping cough in immunised and unimmunised children.

The incidence of whooping cough among immunised children under the age of six and among children of the same age who were not fully immunised was ascertained by analysing whooping-cough notifications from several health authorities. In the first three years of the study the results showed that attack rates were much higher in children who were not fully immunised than in those who were. This fi...

Preparation and Evaluation of Stained Pertussis Antigen for Serodiagnosis of Whooping Cough

Alternative Whooping Cough Vaccines: A Minireview

Bordetella pertussis, the aetiological agent of an acute upper respiratory tract disease of humans, “whooping cough”, can infect all age groups with adolescents and adults acting as major source of transmission of this pathogen to infants. This transmission is promoted by the fact that adolescents and adults do not exhibit the characteristic cough, the infection being either asymptomatic or man...

Duration of effectiveness of pertussis vaccine: evidence from a 10 year community study.

A 10 year study of whooping cough in a discrete general practice community was performed to assess longitudinally the efficacy of pertussis vaccine from one to seven years after immunisation. Of the 436 cases of whooping cough over 10 years, 326 occurred in children aged 1-7 years. The rate of immunisation was known for each cohort of children born during each year, and the attack rate of whoop...